ฆสพ.สบส. ๒๙๘๓/๒๕๖๗

Does Vitaran really reduce melasma? Does polynucleotide only give the skin a dewy, radiant look?

Vitaran and all PN products are truly effective in treating melasma by reducing inflammation and repairing and strengthening the skin's structure. Yes

A good PN (Protein-Intensive Cellulose) must have the right molecular size, which is 390-1300 KDA, because it can effectively stimulate collagen production and reduce inflammation.

Although its primary function is to create a dewy, radiant complexion, it also improves skin health from within. The problem of pigmentation and the distribution of melasma will improve noticeably. Especially in patients with thin skin or chronic melasma, PN injections can help the skin withstand pollution and prolong the effectiveness of other melasma treatments.

If patients have already used creams but feel that the results are not significant enough, or their skin rejects the creams, then moving on to injectable treatments is a suitable option. Combining this with laser treatment would also be appropriate, depending on the severity and type of melasma experienced by each individual.


This information is for informational purposes only and is not intended to recommend any specific innovation/technology. Please schedule an appointment with a doctor for a detailed assessment and advice.

PN isn't just about a "dewy glow," it's about "deep repair at the cellular level."

The primary function of PN (Polynucleotide) group, such as Vitaran or other brands, is... Skin Rejuvenation Yes, it repairs damaged cells and stimulates collagen production.

  • Mechanisms that help with melasma: Although PN is not a direct pigment-removing agent like whitening products, it does have some properties. Reduces skin inflammation (Anti-inflammatory) Yes, inflammation under the skin is the main trigger for melasma. The healthier and less inflamed your skin is, the lower the chance of abnormal melanin production.
  • Comparative example: Ask the patient to visualize that... The ceiling looked like the house was on fire. Using anti-blemish medication is like directly putting out a fire with water, but... PN injection is a method of creating new, strong, and fire-resistant house walls. Yes, when the skin structure improves, the skin will be less sensitive to the sun and less prone to developing new freckles.

Does Vitaran really help reduce melasma?

The answer is "It can be helpful as an adjunctive therapy." Yes, Vitaran will help. Dark spots from melasma appear lighter and skin tone becomes more even. Because the skin becomes denser and healthier, it can naturally and effectively shed dead skin cells.

  • Things to watch out for: If you expect that injecting PN alone will completely erase thick melasma like using correction fluid, the doctor has to be honest and say that it might not be the case. However, it may not be possible to combine it with laser treatment or topical melasma creams. The results will be exponentially better (Synergy Effect). And it significantly reduces the chances of melasma recurring.

The PN group is helping everyone, right?

The basis of PN is also skin repair. "But the concentration and quality are different." Currently, there are many brands, such as Vitaran, Rejuran, or various Healer products. Although they all use salmon DNA extract, Extraction technology and molecular size. It affects penetration and mechanism of action differently.

  • Vitaran: It is often known for restoring moisture and repairing dry skin.
  • Medical techniques: Doctors often choose to use PN for patients with melasma who have thin skin from using strong melasma creams for a long time, because PN will penetrate... "Skin healing" To make your hair thicker and more resistant to sun damage again.

A deep dive into 4 PN-level skin rejuvenation programs: Which one should you choose?

This table is provided so that patients can see the differences in each dimension.

ProgramMain extractความเข้มข้นResult durationKey features / Skin problems emphasized
VITARAN (Korea 🇰🇷)Trout + HA20 mg / 1 Syrup.6-10 monthsFocuses on inflamed, acne-prone skin. Reduces dark spots and redness, and provides moisture (because it contains HA).
Swear (Korea 🇰🇷)salmon20 mg / 1 Syrup.3 – 5 monthsFocuses on enlarged pores. Uneven skin texture; the original Glass Skin look.
PLINEST (Italy 🇮🇹)Trout40 mg / 1 Syr.2 – 3 monthsMaximum concentration Focuses on fine lines, sagging skin, and sensitive skin.
NUCLEO FILL (Italy 🇮🇹)salmon2.5%6 – 10 monthsFocus on lifting and firming. For sensitive, inflamed skin and to treat dull complexion.
Is D' Prompt Glow X2 injection for reducing melasma better than laser treatment? How many sessions are needed to see results? What is the price? Frequently asked questions.

Comparison table of differences between VITARAN and OXELLE.

หัวข้อVITARAN (focuses on deep repair)OXELLE (focuses on protection and brightening)
Main featuresSkin structure repair (DNA Repair)Antioxidant
Skin resultsHealthy, supple skin with a radiant glow. Glass Skinsmooth skin Even skin tone, not dull.
problem solvingReduces dark spots, redness, and wrinkles in the long term.Restore skin that has been damaged by... Sunlight and pollution
MoistureFocuses on radiant, hydrated, and healthy-looking skin.Hydrates and creates a protective skin barrier.
Who is it suitable for?The patient Thin, sensitive skin Or, your skin is damaged and needs repair.The patient Dull skin Frequent exposure to sunlight or dust and pollution.

Other frequently asked questions