The secret to glowing skin is not a filter, it's a science.
Have you ever wanted beautiful, radiant "Glass Skin" that looks healthy from within, but found it confusing to choose the right program, especially when faced with similar-sounding PN (Polynucleotide) products like Rejuran and Plinest? Today, I'll answer all your questions and delve into the core of this Italian innovation. Plinest We will explain what it is, how it works, and how it differs from the Rejuran we are familiar with, so that patients can find the answers to achieving beautiful, healthy skin in the long run.
What is Plinest? Skin rejuvenation from Italy with PN-HPT™.
Get to know Polynucleotide (PN), the star ingredient in skin rejuvenation.
Plinest (pronounced ple-nest) This is a premium skin booster from Italy, whose main ingredient is... Polynucleotide (PN) Or, pure DNA fragments extracted from wild salmon, which are very similar to human DNA, ensuring safety and a very low chance of allergic reactions.
What makes Plinest special and unique is its use of exclusive patented technology. PN-HPT™ (Polynucleotide Highly Purified Technology) This process results in a highly pure and concentrated PN, which, when injected into the skin, can deeply revitalize and repair damaged skin cells at the DNA level.
Review of Polynucleotide (PN) skin treatment.
What are the differences between Plinest and Rejuran?
Although Plinest and Rejuran are both polynucleotide (PN) products, there are important differences between them.
- source Plinest extracts PN from... Wild salmon While Rejuran is extracted from... Farmed salmon
- technology Plinest uses technology. PN-HPT™ To obtain high purity PN, Rejuran uses a technology called... DOT™ (DNA Optimizing Technology)
- Concentration and sub-variants Plinest offers a wider variety of concentrations and formulas to address different skin problems more precisely, such as:
- Plinest It has a high concentration of PN. 40 mg. Suitable for rejuvenating the face, neck, and décolleté areas that require restoration of elasticity and reduction of wrinkles.
- Plinest FAST There is a PN. 15 mg. The gel texture is lighter and designed specifically to restore delicate skin areas such as... The skin under the eyes, around the eyes, and around the mouth.
This variety allows doctors to choose the products that best suit their needs. "Specific" This allows us to better address each patient's specific problems and treatment areas.
| Program | Plinest | They swear |
|---|---|---|
| Main benefits | Restores skin health, reduces inflammation, reduces redness, and improves sensitive skin. | Restores and refines skin texture, brightening overall skin tone. |
| Product content | High purity molecules, low irritation. | The product has a thicker consistency, so you might feel the difference more noticeably when you spray it. |
| Injection site | All over the face + under the eyes + areas prone to redness. | The entire face (there may be slight swelling or injection marks). |
| suitable for | Sensitive skin, rosacea-prone skin, tired skin, post-laser recovery, damaged skin barrier. | Uneven skin tone, dull complexion, enlarged pores, suitable for those undergoing skin recovery. |
| Combining with other procedures. | After laser treatment, a wound-causing procedure, a calming recovery period is achieved. | It can be used alone or in combination with skin brightening treatments such as IPL, and it works well. |
| conclude | Ultimate skin repair—ideal for sensitive skin and first-time users. | "Reboot" your skin—ideal for those seeking deeper rejuvenation. |
Review of Polynucleotide (PN) skin treatment.
How many versions of Plinest software are there?
| Minimum Requitrement | Plinest | Plinest FAST |
|---|---|---|
| PN quantity | 40 mg / 1 Syringe | 15 mg / 1 Syringe |
| Recommended areas | All over the face, neck, and décolletage. (Deep skin layer) | Around the eyes, eyelids, around the mouth. (Sensitive skin) |
| Help solve the problem. | – Fine lines and deep wrinkles – Acne scars and blemishes – Large pores – Uneven skin texture – Sagging skin, lacking elasticity. – Weak and dull skin – Dry and rough skin – Prepare the skin before other procedures. | – Fine lines and deep wrinkles (Especially around the eyes) - Rejuvenates the skin around the eyes and increases elasticity. - Reduce dark circles under the eyes. – Skin preparation before eyelid surgery. – Promotes and stimulates hair to become stronger and thicker. – Wrinkles around the lips |
| technology | PN-HPT™ (Polynucleotide Highly Purified Technology) | PN-HPT™ (Polynucleotide Highly Purified Technology) |
| Duration of effect | 2-3 months | 2-3 months |
The 5-step operating mechanism of PN-HPT™
The PN-HPT™ technology in Plinest systematically revitalizes our skin through five key steps:
- It helps stimulate fibroblast activity. It works by stimulating fibroblast cells, the factories that produce collagen and elastin in our skin, to function actively again.
- Create an environment that allows fibroblasts to function effectively. PN-HPT™ helps optimize the skin's environment, allowing fibroblast cells to function and move to repair areas most efficiently.
- Stimulates the production of collagen and elastin. It stimulates the production of new collagen and elastin, and arranges them in an orderly manner, resulting in stronger and more flexible skin structure.
- Helps to improve the effectiveness of fibronectin. It stimulates the production of fibronectin, a protein that acts like "glue," binding collagen and skin structure together, making the skin stronger.
- Helps repair skin and regenerate new skin cells. It repairs the DNA of damaged cells and stimulates the creation of new, youthful, and high-quality skin cells, resulting in overall younger-looking and healthier skin.
Where can Plinest be injected, and what problems does it help solve?
With its range of models to suit different needs, Plinest can provide comprehensive skincare for a wide variety of areas.
- Under-eye skin (Plinest FAST) Suitable for people with problems. Dark circles under the eyes, fine lines around the eyes. Or, for very thin skin under the eyes, Plinest FAST injections can help restore the skin under the eyes, making it thicker and stronger, thus reducing the appearance of dark circles and wrinkles.
- Wrinkles around the mouth and neck (Plinest FAST/Plinest) Helps to restore smooth and firm the skin around the mouth and neck, which is prone to wrinkles.
- The cheek area and the entire face (Plinest) For those who want to restore overall skin quality, increase elasticity, reduce enlarged pores, and achieve smoother, more youthful-looking skin.
- Forehead wrinkles Helps reduce the appearance of fine lines on the forehead caused by skin aging.
- Skin on the pline It can restore the often-neglected skin on the décolletage area, making it firm and smooth again.
What are the differences between Plinest and Profhilo?
Another program that patients often ask about is Profhilo, which I must say has a clearly different goal. Profile The focus will be on replenishment. "Moisture" It is primarily suitable for patients with specific problems. Dry, dehydrated skin while Plinest The focus will be on... "Restores and repairs skin structure." To address sagging skin and wrinkles caused by aging.
| Minimum Requitrement | Plinest | They swear | Profile |
|---|---|---|---|
| Main active ingredients | Polynucleotide (PN) | Polynucleotide (PN) | Hybrid Hyaluronic Acid (HA) |
| Key features/main mechanisms | Repair and restore skin structure. Stimulates collagen production deep within the DNA level. | Skin repair Stimulates the regeneration of new skin cells and reduces inflammation. | Hydrate Adds fullness and a dewy glow, like replenishing moisture to the skin. |
| Key Technology | PN-HPT™ (High purity and concentration) | DOT™ | NAHYCO™ (Combination of large and small HA molecules) |
| producing countries | อิตาลี | South Korea | อิตาลี |
| Suitable for various skin problems. | - Thin skin, lacking elasticity. - Fine lines (especially under the eyes) - Looking to restore skin quality for the long term. | - See More – Reduces inflammation and scarring. – Tightens pores | - Dry, dehydrated skin - Skin lacks firmness and radiance. - Want a dewy, glass skin look. |
| Recommended areas | All over the face, under the eyes, around the mouth. Neck, chest | Apply to the entire face, focusing on areas with acne scars or enlarged pores. | Covering the entire face and neck (injected using the BAP Technique). |
| The feeling when getting the injection. | It will hurt a little (with the help of a local anesthetic). | More painful than the others. (A local anesthetic is used.) | Less painful (with the help of anesthetic). |
| result | Skin becomes stronger, thicker, and wrinkles fade. The results are gradual. | Skin becomes smoother, pores are tightened, and acne scars fade. | The skin becomes moisturized, plump, and radiant. The results were seen quite quickly. |
| Thai FDA | certified | certified | certified |
4 things you should know before deciding to use Plinest software.
1. Is the Plinest program painful?
The sensation during the procedure is only slightly painful, similar to an ant bite when the medication is injected into the skin. A local anesthetic is always applied beforehand. Furthermore, modern injection techniques can be used to reduce the number of needles, making the patient feel more comfortable throughout the procedure.
2. How long does it take to make?
The Plinest program is a very quick procedure; on average, it takes approximately... 15-20 minutes It only takes one application (excluding the time for applying the numbing cream), making it convenient and quick, and it won't disrupt your daily life.
3. How many injections are needed to see results?
To achieve noticeable and long-lasting skin rejuvenation results, the doctor recommends continuing the following treatments.
- To restore overall skin quality: Injection is recommended. 3 times Maintaining a distance of approximately [number] minutes between them. 3-4 weeks
- To treat acne scars: A higher dose may be required; injection is recommended. 2 times But use 2 boxes (4 cc) at a time, with a time interval of approximately... 4 week Yes
Who is not yet suitable for Plinest injections?
For maximum safety, patients should always inform their doctor before any treatment if they have any of the following conditions or diseases.
- People with a history of allergies to medications or food. Especially those with a history of... I'm allergic to salmon. Or have you ever had symptoms? Severe allergic reaction (Anaphylaxis)
- Pregnant and breastfeeding women There is insufficient safety information available yet, so it's best to avoid it for now.
- People with skin problems If the area to be treated has... Inflammation or infection. In the meantime, you should postpone the treatment until your skin has healed.
- People with certain underlying medical conditions.
- Diseases related to blood disorders, or currently taking [medications/products]. Medications that affect blood clotting. (e.g., aspirin, warfarin)
- Diseases related to the immune system, such as: HIV/AIDS or Systemic Lupus Erythemus (SLE)
- ผู้ป่วยมะเร็ง Currently undergoing treatment.
- Diabetic patients For those who still have poor blood sugar control.
- People receiving immunosuppressant treatment.
Possible side effects after a Plinest injection (and how to manage them)
After the injection, patients may experience some symptoms, which are normal skin reactions. It usually resolves on its own within 5-10 days. There's no need to worry.
- Red marks or bruises Small red or bruised areas may appear at the injection site.
- Swelling The skin at the injection site may swell slightly, which is normal.
- Needle scars Small bumps resembling mosquito bites may appear at the injection site, but these will gradually subside and disappear on their own within 12-24 hours.
Basic care instructions: If there is swelling or bruising, you can use... Cold compress Applying the substance to the affected area can help speed up the recovery process. However, if the patient experiences more severe symptoms, such as intense pain, swelling, redness, heat, or signs of infection, they should contact the clinic immediately to consult a doctor.
Self-care after Plinest injection for the best results.
Post-injection self-care is just as important to prevent infection and ensure the best possible results. The doctor recommends following these guidelines.
- Avoid touching the injection site. At least after injection. 12-24 hours Avoid touching, picking, and scratching. No makeup This is to prevent germs from entering the tiny needle marks on the skin.
- Avoid heat and direct sunlight. During First 48 hours Avoid direct sunlight and refrain from activities that expose your face to heat for extended periods, such as saunas, steam rooms, or hot baths, for 1-2 weeks.
- Avoid strenuous exercise. Avoid strenuous exercise that causes excessive sweating for now. First 48 hours Yes
- Do not massage the face. It is very important to avoid massaging, pressing, or rubbing. The injection site must be kept strictly clean for a period of time. 2 week This allows the medication to work effectively in the location where the doctor has placed it, and prevents any potential inflammation.
- drink enough water Drinking plenty of water helps promote plump and hydrated skin, allowing Plinest to work more effectively.
How much does Plinest cost?
| Program | Volume | Price (Baht) |
|---|---|---|
| Plinest FAST (PN 15 mg) | 2 cc | 16,900 |
| Plinest (PN 40 mg) | 2 cc | 25,000 |
Why choose D' Lovevery Clinic?
Choosing a reputable and trustworthy clinic is of utmost importance. Therefore, we are committed to providing you with the best possible experience in every aspect.
- Private and attentive. No long waits, no crowds, doctors provide detailed, case-by-case consultations, and are not rushed.
- Relaxed and free from pressure. There are no salespeople trying to close sales, and no pressure to buy courses.
- Convenient payment options, choose your preferred method. We offer deposit and installment payment options, including Shopee PayLater and 0% interest installments via credit card.
- Continued care by the same doctor. Follow up directly with the treating physician.
- Genuine reviews from real customers. Includes reviews from real users, not celebrities or influencers.
- Highly experienced and verifiable doctors.
- A standard clinic with convenient transportation. The clinic is certified and has free parking.
- Transparent and verifiable. Fast information, easy to check remaining course balance, all products are FDA approved in Thailand and verifiable.
- Paseo Town Ramkhamhaeng Branch Call 064-424-6526
- Crystal Design Center (CDC) branch Call 095-236-4546
Since the beginning of 2026, this has been one of the most frequently asked questions I encounter at my clinic: "Which PN injection is best?" Friends and patients alike are scrambling to find information, asking, "Is this brand or that brand any good?"
Speaking as a cosmetic doctor, I can tell you that... "There's no single best product for everyone, but there's one that's best suited to each patient's individual skin problems." Because skin structure, age, and the concerns we're concerned about are different for everyone, even the same PN (Permanent Makeup) type will yield different results depending on the patient's case.
Group of extracts PN (Polynucleotide) Or what we commonly refer to as... Skin Booster (for radiant skin) This is a deep skin rejuvenation process at the DNA level. Each brand has slightly different strengths and sources of DNA. To provide a clearer picture and make it easier to decide, the doctor has created a summary table of 3 options. Rejuran, Vitaran, and NucleoFill Let's compare them side by side.
Vitaran and all PN products are truly effective in treating melasma by reducing inflammation and repairing and strengthening the skin's structure. Yes
A good PN (Protein-Intensive Cellulose) must have the right molecular size, which is 390-1300 KDA, because it can effectively stimulate collagen production and reduce inflammation.
Although its primary function is to create a dewy, radiant complexion, it also improves skin health from within. The problem of pigmentation and the distribution of melasma will improve noticeably. Especially in patients with thin skin or chronic melasma, PN injections can help the skin withstand pollution and prolong the effectiveness of other melasma treatments.
If patients have already used creams but feel that the results are not significant enough, or their skin rejects the creams, then moving on to injectable treatments is a suitable option. Combining this with laser treatment would also be appropriate, depending on the severity and type of melasma experienced by each individual.
To summarize in the simplest way possible, the program... Skinvive It is an investment in... "Long-term skin quality" Because it's Hyaluronic Acid, which helps... Smooth, radiant, and moisturized skin.The results last a long time. 6-9 months while They swear It will serve as... "Repair unit" Focused on problem solving. Scarring, enlarged pores, and weak skin. Therefore, if the patient desires a dewy, glass skin look, Skinvive might be more suitable. However, if they need to treat damaged skin, require rapid rejuvenation, and see quick results, Rejuran might be recommended. Alternatively, both treatments can be used together for the best results.
This is a modern slang term used by teenagers: "skin covered in foundation." 🙂 The problem of makeup not staying on is often caused by... Dehydrated skin This causes the skin to produce excess oil, pushing makeup aside and causing it to cake. The doctor recommends addressing the root cause by restoring skin balance. The most effective program for this is injection. Skin Booster (there are many types now) To hydrate and create a smooth, protective film on the skin, or if the skin is very sensitive, it should be used. PN (The options are starting to increase.) To repair and strengthen the skin's structure and balance oil production, proper skin preparation is like applying a primer from within, helping... Long-lasting makeup And reveal your beautiful, clear skin with confidence.
If the patient has to choose, the doctor recommends focusing on the primary goal. If that's what they want. "Skin looks radiant and instantly reflects light." Glass Skin option available. Neauvia Hydro Deluxe Because it contains HA and CaHA, which are excellent for moisturizing and firming. However, if the patient is looking for... "Sustainable and long-term skin repair." I want smooth skin, tighter pores, and visible results. Lasts longer (6-12 months) The doctor recommended. Karisma This is Rh Collagen, which focuses on restoring skin to a youthful state.
Take this with a grain of salt, but what I can tell you is that it's not some rare substance or medication. Most of the names and stories are just marketing ploys, but in reality, it's a basic program that needs to be tailored to your specific skin type. Only someone who truly understands skin can provide this advice.
To achieve the perfect "celebrity skin," the doctor concluded that a holistic treatment approach is necessary, starting with... Restoring skin quality With the group PN or Skin Booster Keeps skin hydrated and strong, while also... Reshape the face. With Botox or other skin tightening devices to create a more defined facial contour. Imagine this as the doctor instructs. Take a close look at what we see when we look at good-looking people. We usually only see the well-defined lines of their facial features and smooth, radiant skin. If someone has both of these, they have the skin of a celebrity. And to complete the Brightness With vitamin drips or mesotherapy for facial rejuvenation, the key element is... consistency And selecting procedures that are suitable for the patient's skin condition at each age group.
During injection Plinest You might feel a slight tingling or burning sensation on your skin while the medication is being administered. This is a normal reaction to this type of medication, Polynucleotide (PN). Don't worry, though. We'll apply a numbing cream for about 30-45 minutes before the procedure and use a very small needle to minimize discomfort. Most people will tolerate it comfortably, and the burning sensation will disappear afterward.
